As in the book on which it is based, the series follows the adventures of Miss Rizos and her class composed of eight children (in the original book, the class was about 19 students) who go on a school bus magical anthropomorphic that can take you on excursions within the solar system, to the center of the Earth or within a human body, or any other trip that in real life is totally impossible. The books are written in the first person from the point of view of an anonymous student of the Frizzle class.
From the books of The Magic School Bus scientific facts are presented in the form of stories where fantastic things happen (for example, a bus circulating through space or children as they shrink to the size of blood cells), each book had a page in it. the end of it detailing with a form of humor all the scientific facts represented in the book and part of the plot of the story. In the television version was replaced by a segment that said "Producer Says" at the end of each episode where the producer of the series (voice of Malcolm-Jamal Warner) received phone calls from children asking about things that have happened in the series that could never happen in real life.